The pancreas is one of the largest glands in the body and it is really two grads in one. Almost all of its cells are connected with secretion. The pancreas lies across the upper part of the abdomen in front of the spine and on top of the aorta and the vena cava (the body’s main artery and vein). The duodenum is wrapped round the head of the pancreas. The basic structures in the pancreas are the acini, which are collections of secreting cells around the end of a small duct. Each duct joins up with ducts from other acini until all of them eventually connect with the main duct running down the middle of the pancreas. The Islets of Langerhans are cells that are responsible for the secretion of insulin, which is needed by the constant control of its sugar level. The Islets also produce a hormone called glucagon whose job it is to raise the level of sugar in the blood, rather than lowering it. The pancreas also part in digestion as it secretes digestive enzymes into the small intestine.